Association between Non Alcoholic Fatty Liver Disease and Severity of Coronary Artery Disease in Patients Aged 45 Years and Below with Acute Coronary Syndrome
Published: November 1, 2021 | DOI: https://doi.org/10.7860/JCDR/2021/50612.15690
Alyaa Hassan Ali Eissa, Khairul Najmi Muhammad Nawawi, Mohd Shawal Faizal Mohamad, Zhiqin Wong, Hamat Hamdi Che Hassan, Oteh Maskon, Nur Yazmin Yaacob, Raja Affendi Raja Ali
1. Doctor, Department of Gastroenterology Unit, Faculty of Medicine, The National University of Malaysia, Cheras, Kuala Lumpur, Malaysia.
2. Doctor, Department of Gastroenterology Unit, Faculty of Medicine, The National University of Malaysia, Cheras, Kuala Lumpur, Malaysia.
3. Doctor, Department of Cardiology Unit, Faculty of Medicine, The National University of Malaysia, Cheras, Kuala Lumpur, Malaysia.
4. Associate Professor, Department of Gastroenterology Unit, Faculty of Medicine, The National University of Malaysia, Cheras, Kuala Lumpur, Malaysia.
5. Doctor, Department of Cardiology Unit, Faculty of Medicine, The National University of Malaysia, Cheras, Kuala Lumpur, Malaysia.
6. Doctor, Department of Cardiology Unit, Faculty of Medicine, The National University of Malaysia, Cheras, Kuala Lumpur, Malaysia.
7. Associate Professor, Department of Radiology, Faculty of Medicine, The National University of Malaysia, Cheras, Kuala Lumpur, Malaysia.
8. Professor, Department of Gas
Correspondence
Dr. Raja Affendi Raja Ali,
Gastroenterology Unit, Faculty of Medicine, The National University of Malaysia,
Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur-56000, Malaysia.
E-mail: draffendi@ppukm.ukm.edu.my
Introduction: Coronary Artery Disease (CAD) is an important extrahepatic cardiovascular complication of Non Alcoholic Fatty Liver Disease (NAFLD).
Aim: To determine the prevalence of NAFLD in young (≤45 years) Acute Coronary Syndrome (ACS) patients, and to assess the association between severity of NAFLD and severity of CAD.
Materials and Methods: This cross-sectional study was conducted from May 2017-April 2018, with a total of 85 patients. CAD severity was determined by coronary angiogram while its complexity by SYNTAX score. Fatty liver was diagnosed and graded by liver ultrasound examination.
Results: The prevalence of NAFLD was 100%. Thirty-three (38.9%) had ST-Elevation Myocardial Infarction (STEMI), 32 (37.6%) had Non STEMI (NSTEMI) and 20 (23.5%) had unstable angina. There was no significant correlation between NAFLD steatosis grades and ACS subtypes (p=0.721), severity of CAD (p=0.822) and SYNTAX score (p=0.982). No association between NAFLD fibrosis score and ACS subtypes (p=0.232), severity of CAD (p=0.445) or SYNTAX score (p=0.839) were observed.
Conclusion: The NAFLD was extremely prevalent in young ACS patients. However, no significant association between severity of NAFLD and severity of CAD was found.
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